E the complete profile richard on. sign up for alerts, and more, to access your subscriptions, sign up for alerts, and more, to download free article PDFs, sign up for alerts, customize your interests, and more, to make a comment, download free article PDFs, sign up for alerts and more, Archives of Neurology & Psychiatry (1919-1959), FDA Approval and Regulation of Pharmaceuticals, 1983-2018, Global Burden of Skin Diseases, 1990-2017, Health Care Spending in the US and Other High-Income Countries, Life Expectancy and Mortality Rates in the United States, 1959-2017, Medical Marketing in the United States, 1997-2016, Practices to Foster Physician Presence and Connection With Patients in the Clinical Encounter, US Burden of Cardiovascular Disease, 1990-2016, Waste in the US Health Care System: Estimated Costs and Potential for Savings, Register for email alerts with links to free full-text articles. Compare the frequency, rapidity and sustainability of PASI 90 and 100 response in patients with moderate‐to‐severe psoriasis treated with brodalumab or ustekinumab. These trials previously showed significantly higher PASI 75, 90 and 100 response rates with brodalumab vs. ustekinumab.10 In the current integrated analysis, a consistently higher proportion of brodalumab‐treated than ustekinumab‐treated patients achieved rapid and consistent complete clearance over the 52‐week treatment period, with significant differences observed from Week 4 onwards. Notably, AMAGINE‐2 and ‐3 excluded patients who had prior ustekinumab experience, resulting in a high number of biologic‐naïve patients in this dataset. The mean (SD) number of days spent in PASI 100 response was 154.7 (124.4) days with brodalumab vs. 91.7 (112.4) days with ustekinumab. Original Research Clinical Efficacy of a Cosmetic Treatment by Crescina® Human Follicle Stem Cells on Healthy Missing data were handled using non‐responder imputation. Terms of Use| Dr Warren has been a consultant for and has received grants from AbbVie, Almirall, Amgen, Avillion, Arena Pharmaceuticals. In this integrated analysis of data from the AMAGINE trials, brodalumab rapidly achieved high levels of complete and sustained skin clearance and a greater overall cumulative treatment benefit in patients with moderate‐to‐severe psoriasis through 52 weeks vs. ustekinumab. Dr. Reich has been a consultant for and/or has received honoraria and/or investigator fees from AbbVie, Affibody, Almirall, Amgen, Biogen‐Idec, Boehringer Ingelheim; Bristol‐Myers Squibb, Celgene, Covagen, Eli Lilly, Forward Pharma, Fresenius Medical Care, Galapagos, GlaxoSmithKline, Janssen, Kyowa Kirin, LEO Pharma, Medac, Merck Sharp & Dohme, Miltenyi, Novartis, Ocean Pharma, Pfizer, Samsung Bioepis, Sandoz, Sanofi, Sun Pharma, Takeda, UCB Pharma, Valeant, XBiotech and Xenoport. A higher proportion of patients who achieved PASI 100 also achieved DLQI 0/1 (83.5%) vs. PASI 90 to <100 (64.3%). Brodalumab.

Cumulative benefit (nominal AUC value) for PASI 100 was 2251 (43.3%) for brodalumab vs. 1332 (25.6%) for ustekinumab, with a treatment difference of 919 (17.7%; P < 0.0001). In his early years in this post, he bolstered and solidified the status of the journal. There was significant positive association between PASI response level and DLQI0/1 achievement (P < 0.0001). Cumulative incidence of achieving PASI 90 at least once over 52 weeks was also higher 87.3% (95% CI, 83.3, 90.5) with brodalumab vs. 71.4% (95% CI, 67.6, 74.8) for ustekinumab (HR 2.08; 95% CI, 1.78, 2.43; P < 0.0001).

By continuing to use our site, or clicking "Continue," you are agreeing to our, 2020 American Medical Association. Online Version of Record before inclusion in an issue. Percentage of patients achieving (a) PASI 100 and cumulative benefit (AUC as % of maximum AUC value) and (b) PASI 90 and cumulative benefit (AUC as % of maximum AUC value) at each time point. Other studies show that patients with complete clearance report no impairment in health‐related QoL, while having even minimal residual disease activity may continue to negatively affect QoL.26, 34 In an analysis of 188 patients with moderate‐to‐severe psoriasis in Phase II placebo‐controlled trials of brodalumab, those with residual disease (sPGA 1) had a DLQI of 2.5 and experienced more severe scaling, redness, itching and flaking than those who were clear (PGA 0).26 In this study, PASI 100 responders were more likely to have DLQI scores of 0/1 (67%) than those with PASI 90 to <100 (40%), implying that a substantial benefit can be achieved by aiming for complete clearance.

At the end of the maintenance phase, 90.1% (95% CI, 86.2, 94.2%) of patients who achieved PASI 100 with brodalumab had sustained response vs. 76.7% (95% CI, 66.8–88.2%) on ustekinumab. Our findings further demonstrated that complete skin clearance is achievable with biologics in many patients with plaque psoriasis, suggesting that this outcome could be the new standard for which to aim. Cumulative benefit considering rapidity, frequency and sustainability of response has not been thoroughly investigated. Richard Warren (Dr) Senior Lecturer and Honorary Consultant Dermatologist Dr Richard Warren graduated from Liverpool University with a first class honours degree in Pharmacology and gained his Medical degree, with honours, one year later. A total of 929 patients (brodalumab 210 mg, n = 339; ustekinumab, n = 590) from AMAGINE‐2 and ‐3 were included in the analyses of skin clearance and cumulative treatment benefit. Cumulative benefit for PASI 90 was 3192 (61.4%) for brodalumab vs. 2252 (43.3%) for ustekinumab, with a treatment difference of 940 (18.1%; P < 0.0001) (Fig. In AMAGINE‐2 and AMAGINE‐3 (Figure S1b), patients were randomized 2 : 2 : 1 : 1 to receive brodalumab 210 mg, brodalumab 140 mg, ustekinumab (45 mg for patients with a body weight ≤100 kg and 90 mg for patients >100 kg on Day 1, Week 4, and Q12W thereafter) or placebo on Day 1, as well as Weeks 1, 2, 4, 6, 8 and 10.

Richard Warren Pugh Theatre Credits, News, Bio and Photos img. Overall, a higher proportion of time was spent in PASI 100 response on brodalumab (42.5%) than ustekinumab (25.2%) (Fig.

PASI 100 responders appeared more likely to achieve DLQI 0/1 than those with PASI 90. All Rights Reserved, 1977;112(1):16-17. doi:10.1001/archsurg.1977.01370010018002, Challenges in Clinical Electrocardiography, Clinical Implications of Basic Neuroscience, Health Care Economics, Insurance, Payment, Scientific Discovery and the Future of Medicine, United States Preventive Services Task Force. The physical, psychological, social and economic burden of psoriasis may cumulatively result in failure to achieve ‘full life potential’ in some patients, a concept known as ‘cumulative life course impairment’ (CLCI).27-29 As the impact of psoriasis is continuous, cumulative treatment benefit using an area‐under‐the‐curve (AUC) analysis should be considered.30 This estimates total time spent at a particular PASI response level, capturing the rapidity and sustainability of response. doi:10.1001/archsurg.1977.01370010018002. 3). Enter your email address below and we will send you your username, If the address matches an existing account you will receive an email with instructions to retrieve your username. Corresponding Author. Boehringer Ingelheim, Celgene, Eli Lilly, Janssen, LEO Pharma, Novartis, Pfizer, Sanofi and UCB Pharma. We report an integrated analysis of the AMAGINE Phase III randomized controlled trials evaluating proportions of patients achieving PASI 100 and PASI 90 with brodalumab vs. ustekinumab [a human immunoglobulin G1κ (IgG1κ) monoclonal antibody targeting the p40 subunit that is common to IL‐12 and IL‐23] over 52 weeks. How lone Mayflower traveller protected his family in ... img.

E‐mail: richard.warren@manchester.ac.uk, Institute for Health Services Research in Dermatology and Nursing, University Medical Center Hamburg‐Eppendorf, Skinflammation® Center, Hamburg, Germany, Toulouse University and Larrey Hospital, Toulouse, France, Department of Dermatology, Hospital de la Santa Creu i Sant Pau, Universitat Autònoma de Barcelona School of Medicine, Barcelona, Spain.

Any queries (other than missing content) should be directed to the corresponding author for the article. In conclusion, this analysis demonstrated that treatment with brodalumab results in very high levels of complete and sustained skin clearance and greater overall cumulative treatment benefit in patients with moderate‐to‐severe psoriasis than ustekinumab. Armstrong et al. The likelihood of achieving complete clearance was numerically greater for brodalumab than ustekinumab at all time points assessed, from Week 2, and was significant from Week 4 (OR 15.5; 95% CI, 5.4, 44.4), with ORs at Weeks 12 and 52 of 2.8 (95% CI, 2.1, 3.8) and 2.8 (95% CI, 2.1, 3.7), respectively(all P < 0.0001). In his early years in this post, he …

Sustained response was evaluated by time to inadequate response using Kaplan–Meier methods. Overall, treatment groups were well balanced in terms of patient demographics and baseline characteristics (Table 1). All Rights Reserved.

All Rights Reserved. Proportion of time spent in treatment response.

All patients provided written informed consent.

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